Targeted Delivery of Cordycepin to Liver Cancer Cells Using Transferrin-conjugated Liposomes

• DOI: 10.21873/anticanres.11944
• Publication Date: 2017-09-06T21:23:45Z
• Authors: Ye Bi; Yulin Zhou; Mengqiao Wang; Lianlian Li; Robert J. Lee; Jing Xie; Lesheng Teng
• Keywords: Cordycepin; Nanocarriers; Transferrin receptor

Background/Aim: Cordycepin is an endogenous nucleoside with significant anticancer biological activity. The objective of this study was to develop targeted liposomes improve solubility and activity cordycepin. Materials Methods: We established transferrin-conjugated deliver cordycepin liver cancer cells evaluated the uptake effect. Results: were loaded Their average size 125.3 nm, drug encapsulation efficiency 65.3%. had good colloidal stability released slowly. Liposomal shown increase reactive oxygen species production cause depolarization mitochondrial transmembrane in cells. Cellular liposomal enhanced by conjugation transferrin, that facilitated receptor-mediated endocytosis. Conclusion: Transferrin-conjugated are effective as nanocarriers for delivery