Physiologic Response to the Pfizer-BioNTech COVID-19 Vaccine Measured Using Wearable Devices: Prospective Observational Study

• DOI: 10.2196/28568
• Publication Date: 2021-06-14T22:01:30Z
• Authors: Alexander G Hajdu...; Kara M DiJoseph; Brinnae Bent; Audrey K Thorp; Jon B Mullholand; Stuart A MacKay; Sabrina Barik; Jamie J Coleman; Catharine I Paules; Andrew Tinsley
• Keywords: Reactogenicity

Background The Pfizer-BioNTech COVID-19 vaccine uses a novel messenger RNA technology to elicit protective immune response. Short-term physiologic responses the have not been studied using wearable devices. Objective We aim characterize changes in response vaccination small cohort of participants device (WHOOP Strap 3.0). This is proof concept for consumer-grade devices monitor vaccines. Methods In this prospective observational study, data from 19 internal medicine residents at single institution that received both doses was collected WHOOP 3.0. primary outcomes were percent change baseline heart rate variability (HRV), resting (RHR), and respiratory (RR). Secondary total, rapid eye movement, deep sleep. Exploratory included local systemic reactogenicity following each dose prophylactic analgesic use. Results individuals (mean age 28.8, SD 2.2 years; n=10, 53% female), HRV decreased on day 1 administration first –13.44%, 13.62%) second –9.25%, 22.6%). RHR RR showed no after either dose. Sleep duration increased up 4 days post vaccination, an initial decrease 1. Increased sleep prior associated with greater HRV. Local more severe two. Conclusions study any vaccines as measured Using relatively healthy cohort, we provide evidence decreases doses, significant or RR. initially subsequent increase thereafter. Future studies larger sample size comparison other inflammatory biomarkers such antibody will be needed determine true utility type continuous monitoring regards responses. Our raises possibility may impact modifiable way These results inform future wearables Trial Registration ClinicalTrials.gov NCT04304703; https://www.clinicaltrials.gov/ct2/show/NCT04304703