Trend of Mortality Due to Congenital Anomalies in Children Younger Than 5 Years in Eastern China, 2012-2021: Surveillance Data Analysis (Preprint)

• DOI: 10.2196/preprints.53860
• Publication Date: 2024-06-03T14:31:02Z
• Authors: Wen-Hong Dong; Jun-Xia Guo; Lei Wang; Shuang-Shuang Zheng; Bing-Quan Zhu; Jie Shao
• Keywords: Preprint

<sec> <title>BACKGROUND</title> As one of the leading causes child mortality, deaths due to congenital anomalies (CAs) have been a prominent obstacle meet Sustainable Development Goal 3.2. </sec> <title>OBJECTIVE</title> We conducted this study understand death burden and trend under-5 CA mortality (CAMR) in Zhejiang, provinces with best medical services public health foundations Eastern China. <title>METHODS</title> used data retrieved from surveillance system Zhejiang 2012 2021. CAMR by sex, residence, age group for each year was calculated standardized according 2020 National Population Census sex- residence-specific live birth Poisson regression models were estimate annual average change rate (AACR) obtain ratio between subgroups after adjusting when appropriate. <title>RESULTS</title> From 2021, total 1753 children died CAs, declined 121.2 62.6 per 100,000 births an AACR –9% (95% CI –10.7% –7.2%; &lt;i&gt;P&lt;/i&gt;&amp;lt;.001). The declining also observed female male children, urban rural neonates older infants, AACRs –9.7%, –8.5%, –9.2%, –12%, –6.3%, respectively (all However, no significant reduction aged 1-4 years (&lt;i&gt;P&lt;/i&gt;=.22). Generally, ratios versus infants neonates, 1.18 1.08-1.30; &lt;i&gt;P&lt;/i&gt;&amp;lt;.001), 1.20 1.08-1.32; &lt;i&gt;P&lt;/i&gt;=.001), 0.66 0.59-0.73; 0.20 0.17-0.24; respectively. Among all broad groups, circulatory malformations, mainly caused heart diseases, accounted 49.4% (866/1753) ranked first across years, although it yearly –9.8% (&lt;i&gt;P&lt;/i&gt;&amp;lt;.001). Deaths chromosomal abnormalities tended grow recent not (&lt;i&gt;P&lt;/i&gt;=.90). <title>CONCLUSIONS</title> reduced annually, cardiovascular malformations ranking Future research practices should focus more on prevention, early detection, long-term management CAs comprehensive support families improve their survival chances.