Lung Cancer Associated With Cystic Airspaces

• DOI: 10.2214/ajr.11.7812
• Publication Date: 2012-09-20T14:23:48Z
• Authors: Ali O. Farooqi; Matt Cham; Lijuan Zhang; Mary Beth Beasley; John H. M. Austin; Albert Miller; Javier J. Zulueta; Heidi Roberts; Cole Enser; Shang-Jyh Kao; M. K. Thorsen; James P. Smith; Daniel M. Libby; Rowena Yip; David F. Yankelevitz; Claudia I. Henschke
• Keywords: Male; Lung Neoplasms; Cysts; Adenocarcinoma; Middle Aged; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Humans; Female; Tomography, X-Ray Computed; Aged

The objectives of this study were to determine the frequency lung cancers associated with a discrete cystic airspace and characterize morphologic pathologic features cancer airspace.We reviewed all diagnosed cases resulting from baseline screening (n=595) annual (n=111) in International Early Lung Cancer Action Program identify those abutting or wall airspace. We also specimens.A total 26 identified Of these, 13 at (13/595, 2%) (13/111, 12%), which was significant (p<0.0001). median circumferential portion involved less for than ones, but difference did not reach significance (90° vs 240°, p=0.07). diagnosis adenocarcinoma three cases. Histologic analysis showed that space bulla, fibrous walled cyst without defined lining, pleural bleb one case, tumor eccentric relative unevenly thickened.At repeat CT screening, finding an isolated increased thickness should raise suspicion cancer.