Impact of CYP2C8 and 2C9 Polymorphisms on Coronary Artery Disease and Myocardial Infarction in the LURIC Cohort

• DOI: 10.2217/pgs.10.96
• Publication Date: 2010-11-03T16:37:45Z
• Authors: Elisabeth Haschke...; Julia Kirchheiner; Olivia Trummer; Gerda Grünbacher; Alexander Kainz; Bernhard O Boehm; Winfried März; Wilfried Renner
• Keywords: Dyslipidemia

Aims: As data on the cardiovascular risk associated with CYP2C8 and CYP2C9 polymorphisms is controversial, we performed a cross-sectional analysis of subjects enrolled in Ludwigshafen Risk Cardiovascular Health (LURIC) study. Materials & methods: genetic were determined real-time PCR 2827 patients. Based angiography, 1052 these patients had coronary artery disease (CAD) 615 did not; 1160 signs or history myocardial infarction (MI) addition to CAD. The association genotypes CAD MI was by logistic regression analysis, adjusted for age, sex, dyslipidemia, hypertension, diabetes mellitus smoking status. Results: Frequencies 2C9 variants neither significantly different between control patients, nor Men carrying CYP2C9*3 allele an increased (odds ratio [OR]: 1.67; 95% CI: 1.06–2.63; p = 0.03) women decreased (OR: 0.65; 95%CI: 0.42–0.9; 0.05). Conclusion: Overall, LURIC confirmed that there no major population having undergone angiography.