Metformin Resistance Alleles in Polycystic Ovary Syndrome: Pattern and Association With Glucose Metabolism

• DOI: 10.2217/pgs.13.223
• Publication Date: 2014-02-17T18:10:01Z
• Authors: Natascha Schweigh...; Elisabeth Lerchbaum; Olivia Trummer; Verena Schwetz; Thomas Pieber; Barbara Obermayer...
• Keywords: Carbohydrate Metabolism; Pharmacodynamics

Insulin-sensitizer treatment with metformin is common in polycystic ovary syndrome (PCOS). OCT alleles were investigated PCOS patients to identify genetic 'bad responders' and 'nonresponders' including their possible effects on glucose metabolism without treatment. We genotyped eight SNPs OCT1, OCT2 ATM genes 676 women 90 control women, we also measured oral tolerance tests prior Nonfunctional present 29.8% low-functional 57.9% of our cohort. variants significantly associated elevated baseline glucose-induced C-peptide levels PCOS. Metformin bad responders or nonresponders based genotypes might be relevant clinical practice – modulation pharmacokinetics pharmacodynamics metformin-independent remain elucidated. Original submitted 7 June 2013; Revision 28 October 2013