Genetic Risk Signatures of Opioid-Induced Respiratory Depression Following Pediatric Tonsillectomy

• DOI: 10.2217/pgs.14.137
• Publication Date: 2014-12-10T16:08:28Z
• Authors: Jacek Biesiada; Vidya Chidambaran; Michael Wagner; Xue Zhang; Lisa J Martin; Jaroslaw Meller; Senthilkumar Sadh...
• Keywords: Depression

Background: Respiratory depression is a clinically and economically important but preventable complication of opioids. Genetic factors can help identify patients with high risk for respiratory depression. Methods: In this prospective genotype blinded clinical study, we evaluated the effect panel variants in candidate genes on opioid-related 347 children following tonsillectomy. Results: Using unsupervised hierarchical clustering combination genotypes variables, identified several distinct clusters at (36-38%) low (10-17%) depression; relative versus was 2.1-3.8 (p = 0.003). Conclusion: predictions (genetic signatures) along effectively higher lower risks opioid-induced signatures offer strategies improved decision support to guide clinicians balance opioid adverse effects analgesia. Original submitted 9 July 2014; Revision 19 September 2014.