Controlled Release of Thymosin β4 from Injected Collagen–Chitosan Hydrogels Promotes Angiogenesis and Prevents Tissue Loss After Myocardial Infarction

• DOI: 10.2217/rme.12.35
• Publication Date: 2012-07-21T00:40:18Z
• Authors: Loraine LY Chiu; Lewis A Reis; Abdul Momen; Milica Radisic
• Keywords: Thymosin

Acute myocardial infarction (MI) leads to fibrosis and severe left ventricular wall thinning. Enhancing vascularization within the infarct reduces cell death maintains a thick wall, which is essential for proper cardiac function. Here, we evaluated controlled delivery of thymosin β4 (Tβ4), supports cardiomyocyte survival by inducing upregulating Akt activity, in treatment MI.