Evaluating the Antifungal Potential of Cinnamaldehyde: A Study of its Efficacy against Candida Species

• DOI: 10.22207/jpam.18.4.16
• Publication Date: 2024-11-13T12:03:17Z
• Authors: R. Rachel; M. Anuradha; K.V. Leela
• Keywords: antimycotic agent; minimum inhibitory concentration (mic); 0106 biological sciences; minimum fungicidal concentration (mfc); disc volatilization assay; disc diffusion assay; Microbiology; 01 natural sciences; QR1-502

Candida species exist as commensals in nature, colonizing the mucous membranes, gastrointestinal tract, vagina well skin and usually cause infections immunocompromised patients. C. albicans are known to be most prevalent associated with infections, while there has been a significant surge incidence of Non-Candida (NCAC) recently. The recent occurrences antifungal resistance Candida, especially NCAC quite alarming which raises need for safe efficient alternative antimycotic drug. This study analyses efficacy cinnamaldehyde against species, is majority fungal humans. Cinnamaldehyde natural antimicrobial compound derived from cinnamon demonstrated properties. Antifungal susceptibility profiles were studied by disc diffusion broth microdilution assays. mean diameter inhibition zone (IZ) formed direct contact volatilization assays 61.26 mM 65.20 mM, respectively. Both minimum inhibitory concentration (MIC) fungicidal (MFC) ranged 16-256 mg/L MIC 60.61 MFC 81.94 mg/L. Co-incubation cells resulted loss viable within 4 hours incubation. was found exhibit both fungistatic properties, making it potent conventional agents.