In vitro antimicrobial and cytotoxic effects of Talaromyces islandicus T101 from a polluted environment

• DOI: 10.22533/at.ed.813272220108
• Publication Date: 2022-11-22T18:59:11Z
• Authors: Igor Vinícius Pim...; Katia Regina Assu...; Neurene da Cruz; Amanda Mara Teles; Marcos Antônio Cu...; Marcos Antônio Cu...; Rita de Nazaré Si...; Marcelo Souza de ...; André Salim Khayat; Jaqueline Diniz P...; André Alvares Mar...; Sulayne Janayna A...; Jerônimo Conceiçã...; Maria do Desterro...; Geusa Felipa de B...

Talaromyces islandicus TI01 was isolated from a marine-influenced environment that has been suffering for decades anthropogenic actions in its body of water.Broth microdilution technique performed to analyze the antimicrobial activity.For analysis cytotoxic activity, MTT [3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide] assay conducted.The chemical extract by LC/MS (liquid chromatography coupled mass spectrometry).The minimum bactericidal concentration (MBC) T. E. coli ATCC 25922 and S. aureus 25923 1000 μg/ml.The inhibitory (MIC) 250 μg/ mL 500 μg/mL, respectively, whereas C. tropicalis 1369 62.5 μg/mL.IC50 breast cancer cell line (MCF-7) 45.43 ± 1.657 μg / mL.The major compounds present were: Luteoskyrin (1) N-GABA-PP-V (6-[(Z)-2-Carboxyvinyl]-N-GABA-PP-V) (2).The results show prominent antibacterial activity against aureus, making this fungi development new food preservatives.