Sericin improve diabetic cognitive impairment in rats by inhibiting TXNIP/NLRP3 neuroinflammation through SIRT1

• DOI: 10.22541/au.169164744.43514759/v1
• Publication Date: 2023-08-10T06:04:24Z
• Authors: Pingjing Wen; Dan Yi; Guangqiu Qin; Jinyue Li; Yuqiu Gao; Haichen Cui; Yixin Ye; Ziheng Xu; Haixin Liu; Liping Wu; Xianjin Lei; Yue Wu; Pei Qin; Yiyi Ling; Yuanzhao Zhou; Yuyi Chen; Jiaheng Du; Baiqing Dong
• Keywords: Sericin

Aims : The aim of this study was to examine the effects sericin on diabetic cognitive impairment (DCI) in rats based neuroinflammation. Methods: SD were firstly fed with high sugar and fat diet for 4 weeks, then injected 50 mg/kg streptozotocin intraperitoneally establish a model. randomly divided into 3 groups treated distilled water (n=10), 500 (n =10) 1000 (n=20) sericin, respectively, by gavage once day 8 weeks. Before end trail, 10 group μg EX527 (a SIRT1 inhibitor) lateral ventricles every other 5 times. Results: Treated significantly reduced fasting blood glucose, improved DCI rats. Sericin inhibited neuroinflammation, expression NLRP3, TXNIP proteins cell apoptosis, while increased protein hippocampus After inhibiting EX527, above effect weakened. Conclusions: These results indicated that may block progression TXNIP/NLRP3 neuroinflammation neuronal apoptosis though SIRT1.