Respiratory infection induced episode of alveolar hemorrhage in the pediatric diffuse alveolar hemorrahge: a retrospective single-center study

• DOI: 10.22541/au.171716691.15524409/v1
• Publication Date: 2024-05-31T14:48:42Z
• Authors: Qing Wei; Xun Chen; Yan Li; Chunyan Li; Xiaobo Zhang; Guangmin Nong; Jing Liu
• Keywords: Diffuse alveolar hemorrhage; Single Center; Diffuse alveolar damage; Center (category theory)

Background Respiratory infection is a common trigger for the episode of alveolar hemorrhage in pediatric diffuse hemorrahge (DAH). Whereas, futher detailed study hasn’t been conducted. The aim this was to explore etiological spectrum, clinical features, treatment strategies and outcomes respiratory induced (RIIEAH) DAH. Methods cases DAH who had RIIEAH definite diagnosis were included. A retrospective Results 1. total 16 with 21 RIIEAHs Twelve occurred at unstable stage, 6 stable stage 3 end stage. All failure (n=5) requirment invasive mechanical ventilation (n=3) or 2. In majority (n=19), identified by detecting nucleic acid pathogens. Of these, bronchoalveolar lavage fluid most commonly used specimen 12 RIIEAHs. (n=19) caused single pathogen including mycoplasma pneumoniae (Mp) 7 RIIEAHs, coronavirus (CoV) haemophilus influenzae (Hi) chlamydia 2 human metapneumovirus acinetobacter baumannii 1 pueumocystis carinii RIIEAH. rest mixed pathogens klebsiella streptococcus RIIEAH, rhinovirus CoV 3. presented prodromal symptoms them (n=15) within days from symptoms. Either worsening anemia hemoptysis found 13 dyspnea 9 which bronchosopy performed bleeding on bronchoscopy. 4. An intensive glucocorticoid therapy administrated 19 targeted anti-infection 11 resolved, whereas there case death. Conclusions could be varity occur any disease It usually early hemoptysis. Bronchoscopy good diagnostic value idenifying etiology. seemed effective necessary.