Drug-induced cardiovascular disorders

• DOI: 10.22730/jmls.2015.12.1.20
• Publication Date: 2022-05-30T04:29:15Z
• Authors: Eunkyoung Lee; Jaechun Lee; HyeJung Han

Adverse drug reactions (ADRs) affecting cardiovascular system might be underestimated and underreported in clinicalpractice. Most common culprit drugs are anthracyclines, antipsychotics and cyclooxygenase (COX)-2 inhibitors. Anthracyclinesmay induce myocardial damage with oxidative stress, which is mostly irreversible. Type I ADRs are commonly encountered inantipsychotic use. Attention should be paid to the risk of sudden cardiac death related to some antipsychotics. COX inhibitorspharmacologically have antithrombotic activities. However, in COX2 selective inhibitors, myocardial infarction and stroke might beinduced paradoxically.