Oxidative DNA Damage and Antioxidant Defense after Reperfusion in Acute Myocardial Infarction

• DOI: 10.2310/jim.0b013e31819d87c1
• Publication Date: 2016-05-11T13:10:57Z
• Authors: Solen Himmetoglu; Yildiz Dincer; Evin Bozcali; Vural Ali Vural; Tulay Akcay
• Keywords: Male; Myocardial Infarction; Deoxyguanosine; Enzyme-Linked Immunosorbent Assay; Myocardial Reperfusion; DNA; Middle Aged; Prognosis; Antioxidants; 3. Good health; Oxidative Stress; 03 medical and health sciences; 0302 clinical medicine; 8-Hydroxy-2'-Deoxyguanosine; Spectrophotometry; Humans; Female; Postoperative Period; Biomarkers; DNA Damage

Purpose Myocardial damage mediated by oxidative stress during acute myocardial infarction (MI) has been suggested as an obstructive factor on recovery after MI. 8-Hydroxydeoxyguanosine (8-OHdG) is a marker for DNA damage; superoxide dismutase (SOD) and glutathione peroxidase (G-Px) are major antioxidant enzymes. We determined changes in the plasma level of 8-OHdG activities SOD G-Px patients with MI examined relations between those other cardiac markers. Methods Blood samples were taken at beginning therapy, third day hospitalization, discharged home. Plasma measured enzyme-linked immunosorbent assay spectrophotometric kits, respectively. Results therapy was found to be decreased With respect treatment way, slightly then remained stable group treated thrombolytic agents. However, sharply that underwent primary percutaneous transluminal coronary angioplasty. No significant parameters serum levels Conclusion Although not correlated markers, shows decrease reperfusion MI, angioplasty seems much more effective than providing low 8-OHdG.