IL-10 and RANTES are Elevated in Nasopharyngeal Secretions of Children with Respiratory Syncytial Virus Infection

• DOI: 10.2332/allergolint.o-06-454
• Publication Date: 2007-06-18T06:18:15Z
• Authors: Hiroki Murai; Akihiko Terada; Mihoko Mizuno; Masami Asai; Yasutaka Hirabayashi; Seiki Shimizu; Takehiro Morishita; Hiroki Kakita; Mohamed Hamed Hus...; Tetsuya Ito; Ineko Kato; Kiyofumi Asai; Hajime Togari
• Keywords: Pathophysiology; Respiratory infection

Respiratory syncytial virus (RSV) infection causes asthma-like symptoms in infants and young children. Although an increase several mediators the airway during RSV has been reported, mechanisms involved inflammation are not fully understood. The aim of this study was to investigate immunological deviation associated with by measuring cytokine chemokine levels infection.One hundred ten children under 3 years age respiratory were enrolled from November 2004 through January 2005. Nasopharyngeal secretions (NPAs) gently aspirated analyzed antigen, thereafter concentrations IL-4, IL-10, IFN-gamma, RANTES measured using ELISA kit. We also investigated prognosis each child after 1 year reference clinical records or interviews re-evaluated levels.Of subjects, 70 positive 40 negative. Only 4 given a diagnosis asthma pediatrician when NPAs collected. significantly higher RSV-positive patients than RSV-negative P values at 0.0362, 0.0007, 0.0047, respectively. In contrast, there no significant difference IFN-gamma. Furthermore, correlation between IL-10 RANTES.The increased production may play important role pathophysiological infection.