Correlation between the Prostaglandin D2/E2 Ratio in Nasal Polyps and the Recalcitrant Pathophysiology of Chronic Rhinosinusitis Associated with Bronchial Asthma

• DOI: 10.2332/allergolint.o-08-545
• Publication Date: 2008-12-11T06:52:02Z
• Authors: Tsuyoshi Yoshimura; Mamoru Yoshikawa; Nobuyoshi Otori; Shin-ichi Haruna; Hiroshi Moriyama
• Keywords: Nasal Polyps; Pathophysiology; Chronic Rhinosinusitis; Pathogenesis

The prevalence of patients with chronic rhinosinusitis (CRS) refractory to traditional therapy appears be on the increase. In these cases, CRS tends associated bronchial asthma (BA), especially, aspirin-intolerant (AIA). On other hand, arachidonic acid metabolites have been extensively investigated in pathogenesis BA. We sought assess role prostaglandin D2 (PGD2) and E2 (PGE2) recalcitrant pathophysiology CRS. Samples were prepared from nasal polyps mucosa 40 undergoing endoscopic sinus surgery (ESS) at our hospital. polyp specimens obtained divided into three groups, as follows: CRS-AIA group, consisting complicated by AIA, CRS-ATA aspirin-tolerant (ATA), CRS-NA without PGD2 PGE2 extracted quantified. concentrations significantly higher group. lowest PGD2/PGE2 ratio was highest It has previously reported that AIA is most likely characterized repeated remissions relapses, thus intractable. may therefore say reflects intractable nature