Hepatic DPP4 DNA Methylation Associates With Fatty Liver

• DOI: 10.2337/db15-1716
• Publication Date: 2016-10-11T16:49:08Z
• Authors: Christian Baumeier; Sophie Saussenthaler; Anne Kammel; Markus Jähnert; Luisa Schlüter; Deike Hesse; Mickaël Canouil; Stephane Lobbens; Robert Caiazzo; Violeta Raverdy; François Pattou; Emma Nilsson; Jussi Pihlajamäki; Charlotte Ling; Philippe Froguel; Annette Schürmann; Robert W. Schwenk
• Keywords: Steatohepatitis; Pathogenesis; CpG site

Hepatic DPP4 expression is elevated in subjects with ectopic fat accumulation the liver. However, whether increased dipeptidyl peptidase 4 (DPP4) involved pathogenesis or rather a consequence of metabolic disease not known. We therefore studied transcriptional regulation hepatic Dpp4 young mice prone to diet-induced obesity. Already at 6 weeks age, was high weight gain, independent liver content. In same animals, methylation four intronic CpG sites decreased, amplifying glucose-induced transcription older mice, triglyceride content only animals expression. Expression and release were markedly higher compared adipose depots. Analysis human biopsy specimens revealed correlation DNA stages hepatosteatosis nonalcoholic steatohepatitis. summary, our results indicate crucial role participation systemic levels. Furthermore, data show that facilitated by demethylation gene early life. This might contribute deteriorations function, which turn result such as later