Relative Pancreas Volume Is Reduced in Autoantibody Negative First-Degree Relatives and Subjects with Pre–Type 1 Diabetes

• DOI: 10.2337/db18-1816-p
• Publication Date: 2018-06-22T18:57:32Z
• Authors: MARTHA CAMPBELL-T...; MARK A. ATKINSON; STEPHANIE L. FILIPP; MATTHEW J. GURKA; RICHARD BEEGLE; DESMOND SCHATZ; MICHAEL J. HALLER
• Keywords: First-degree relatives

Pancreatic size is significantly reduced in new-onset type 1 diabetes (T1D) patients and one study reported decreased weight T1D-related autoantibody (AAb) positive nondiabetic organ donors. We proposed that pancreas volume (PV) could provide important information regarding progression to T1D onset. The relationship between PV status was determined. Study design included 4 groups: < year of diagnosis; AAb+ first-degree relatives (FDR); AAb- FDR; controls. Fasting subjects underwent magnetic resonance imaging (MRI) images were analyzed by radiologists blinded group. Relative (RPV=PV/BMI) utilizing a linear mixed model accounting for age, gender, family clustering with Tukey correction multiple comparisons. A total 223 enrolled overall age 19.6±10.5 years (45% males). RPV higher controls (n=49) than FDR (n=60), (n=62 (single n=30, n=32)) recent onset (n=52) (Figure). also vs. Pancreas MRI demonstrates smaller age-matched have lower those established autoimmunity. may improve our understanding the natural history T1D. Disclosure M. Campbell-Thompson: None. M.A. Atkinson: Other Relationship; Self; Patent Issued. S.L. Filipp: M.J. Gurka: R. Beegle: D. Schatz: Haller: