Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature

• DOI: 10.2337/db19-0157
• Publication Date: 2019-06-19T22:29:03Z
• Authors: Ivan Hernandez-Diaz; Jiaqi Pan; Carlo Alberto Ric...; Xiaoyan Bai; Jianting Ke; Kathryn E. White; Maria Flaquer; Georgia E. Fouli; Fulye Argunhan; Anthea E. Hayward; Fan Fan Hou; Giovanni E. Mann; Robert Q. Miao; David A. Long; Luigi Gnudi
• Keywords: Albuminuria

Damage to the vasculature is primary mechanism driving chronic diabetic microvascular complications such as nephropathy, which manifests albuminuria. Therefore, treatments that protect have significant therapeutic potential. Soluble neurite outgrowth inhibitor-B (sNogo-B) a circulating N-terminus isoform of full-length Nogo-B, plays key role in vascular remodeling following injury. However, there currently no information on sNogo-B context nephropathy. We demonstrate overexpression circulation ameliorates kidney disease by reducing albuminuria, hyperfiltration, and abnormal angiogenesis protecting glomerular capillary structure. Systemic mice also associates with dampening endothelial growth factor-A signaling nitric oxide synthase, AKT, GSK3β phosphorylation. Furthermore, prevented impairment tube formation, occurred when human cells were exposed sera from patients disease. Collectively, these studies provide first evidence protects diabetes may represent novel target for complications.