Plasma Resistin, Associated With Single Nucleotide Polymorphism −420, Is Correlated With Insulin Resistance, Lower HDL Cholesterol, and High-Sensitivity C-Reactive Protein in the Japanese General Population

• DOI: 10.2337/dc06-1936
• Publication Date: 2007-05-25T20:13:49Z
• Authors: Haruhiko Osawa; Yasuharu Tabara; Ryuichi Kawamoto; Jun Ohashi; Masaaki Ochi; Hiroshi Onuma; Wataru Nishida; Kazuya Yamada; Jun Nakura; Katsuhiko Kohara; Tetsuro Miki; Hideichi Makino
• Keywords: Resistin; SNP

OBJECTIVE—Resistin, secreted from adipocytes, causes insulin resistance in rodents. We previously reported that the G/G genotype of a resistin gene promoter single nucleotide polymorphism (SNP) at −420 increases type 2 diabetes susceptibility by enhancing activity. report here on relation between plasma and either SNP or factors related to resistance. RESEARCH DESIGN AND METHODS—We cross-sectionally analyzed 2,078 community-dwelling Japanese subjects attending yearly medical checkup. The was determined TaqMan analysis. Fasting measured using an enzyme-linked immunosorbent assay kit. RESULTS—Plasma associated with (P < 0.0001), which highest followed C/G C/C. Plasma higher elderly individuals, female subjects, nondrinkers, high blood pressure 0.001, 0.003, <0.001, respectively). Simple regression analysis revealed age, sex, homeostasis model assessment (HOMA-IR) index, systolic pressure, low HDL cholesterol, high-sensitivity C-reactive protein (hs-CRP) were positively correlated 0.004, Multiple adjusted for BMI independent factor HOMA-IR, hs-CRP = 0.006, CONCLUSIONS—Plasma resistance, serum general population.