Homocysteine and Diabetic Retinopathy

• DOI: 10.2337/dc07-0632
• Publication Date: 2007-12-28T16:54:25Z
• Authors: Laima Brazionis; Kevin Rowley; Catherine Itsiopo...; Colin Alexander H...; Kerin O’Dea
• Keywords: Adult; Glycated Hemoglobin; Male; 1111 (four-digit-FOR); Diabetic Retinopathy; 610; Blood Pressure; Middle Aged; 3. Good health; 03 medical and health sciences; Cross-Sectional Studies; Folic Acid; 0302 clinical medicine; Risk Factors; Odds Ratio; Humans; Female; Fluorescein Angiography; Homocysteine; Life Style; Biomarkers; Aged

Homocysteine is an emerging risk factor for cardiovascular and nondiabetic ocular vaso-occlusive diseases. However, studies of the relationship between homocysteine diabetic retinopathy have reported inconsistent results. The purpose this study was to evaluate plasma total concentration retinopathy.We assessed homocysteine-retinopathy in 168 men women with type 2 diabetes a community-based, cross-sectional study. We photodocumented status measured using commercial fluorescence polarization immunoassay enzymatic kit. Data selected clinical/demographic variables established factors were obtained from fasting blood samples interviewer-assisted lifestyle questionnaire.A higher mean observed individuals than those without (11.5 mumol/l [95% CI 10.4-12.5] vs. 9.6 [9.1-10.2], P = 0.001). Furthermore, not explained by renal dysfunction independent other major (duration diabetes, A1C, systolic pressure) determinants concentrations (age, sex, red cell folate) (odds ratio 1.20 1.023-1.41], 0.024).Plasma may be useful biomarker and/or novel increased people diabetes.