Influence of Maternal Obesity on Insulin Sensitivity and Secretion in Offspring

• DOI: 10.2337/dc08-0432
• Publication Date: 2008-06-07T00:49:14Z
• Authors: Geltrude Mingrone; Melania Manco; Maria Elena Valer...; Caterina Guidone; Amerigo Iaconelli; Donatella Gniuli; Laura Leccesi; Chiara Chiellini; Giovanni Ghirlanda
• Keywords: Adult; Male; 0301 basic medicine; 2. Zero hunger; Cardiovascular and Metabolic Risk; Puberty; Mothers; Lipids; 3. Good health; 03 medical and health sciences; Adipose Tissue; Diabetes Mellitus, Type 2; Reference Values; Insulin Secretion; Humans; Insulin; Female; Adiponectin; Obesity; Age of Onset; Insulin Resistance; Child

OBJECTIVE—The purpose of this study was to clarify the effects maternal obesity on insulin sensitivity and secretion in offspring. RESEARCH DESIGN AND METHODS—Fifty-one offspring both sexes obese (Ob group) 15 normal-weight (control mothers were studied. Plasma glucose, insulin, C-peptide measured during an oral glucose tolerance test (OGTT). Insulin calculated using index, β-cell computed by a mathematical model. Fasting leptin adiponectin also measured. Body composition assessed dual-X-ray absorptiometry. RESULTS—No birth weight statistical difference observed two groups. Of Ob group, 69% 19% overweight. The group more resistant than control (398.58 ± 79.32 vs. 513.81 70.70 ml−1 · min−1 m−2 women, P < 0.0001; 416.42 76.17 484.242 45.76 men, 0.05). after OGTT higher men (63.94 21.20 35.71 10.02 nmol m−2, 0.01) but did not differ significantly women. β-Cell statistically different between A multivariate analysis variance showed that sex concurred together with BMI determine differences CONCLUSIONS—Obese can give normal babies who later develop resistance. genetic/epigenetic transmission shows clear sexual dimorphism, male having value (although significant) associated female