Combined Measurement of Fasting Plasma Glucose and A1C Is Effective for the Prediction of Type 2 Diabetes

• DOI: 10.2337/dc08-1631
• Publication Date: 2009-01-09T01:56:08Z
• Authors: Kyoko Kogawa Sato; Tomoshige Hayashi; Nobuko Harita; Takeshi Yoneda; Yoshiko Nakamura; Ginji Endo; Hiroshi Kambe
• Keywords: Adult; Blood Glucose; Glycated Hemoglobin; Male; Reproducibility of Results; Fasting; Middle Aged; 03 medical and health sciences; 0302 clinical medicine; Diabetes Mellitus, Type 2; Japan; ROC Curve; Predictive Value of Tests; Humans; Original Research; Follow-Up Studies

OBJECTIVE We prospectively assessed whether the combined measurements of fasting plasma glucose (FPG) and A1C were effective for predicting type 2 diabetes. RESEARCH DESIGN AND METHODS Study participants included 6,736 nondiabetic Japanese men aged 40–55 years. Type diabetes was diagnosed in those who had an FPG ≥126 mg/dl or being treated with oral antidiabetic agent insulin. The models including FPG, A1C, both compared using area under receiver operating characteristic (AUROC) curves. RESULTS During 4-year follow-up period, we confirmed 659 cases. In multivariate analysis, independently associated risk model a greater AUROC curve than that alone (0.853 vs. 0.818; P < 0.001) 0.771; 0.001). CONCLUSIONS measurement