Microalbuminuria, Preeclampsia, and Preterm Delivery in Pregnant Women With Type 1 Diabetes

• DOI: 10.2337/dc09-1219
• Publication Date: 2009-10-22T02:12:25Z
• Authors: Dorte M. Jensen; Peter Damm; Per Ovesen; Lars Mølsted-Pede...; Henning Beck-Nielsen; Jes G. Westergaard; Margrethe Moeller; Elisabeth R. Math...
• Keywords: Microalbuminuria; Albuminuria

OBJECTIVE To study the association between microalbuminuria and development of preeclampsia preterm delivery in pregnant women with type 1 diabetes. RESEARCH DESIGN AND METHODS This was a population-based prospective 846 normoalbuminuric or microalbuminuric diabetes without antihypertensive treatment early pregnancy. Data were collected prospectively by one to three caregivers each center reported central registry. RESULTS The prevalence first trimester 10%, median duration 11 years, third-trimester A1C 6.6%. frequencies before 34 weeks group 40 13%, both significantly higher than those (12 6%, respectively, P < 0.001). After adjustments for possible confounders, significant predictors (odds ratio 4.0 [95% CI]), nulliparity (3.1 [1.9–5.1]), (1.3 [1.1–1.5] per 1% increase). Delivery associated univariate analyses, but multivariate analyses only predictor this outcome. Preeclampsia threefold risk weeks. CONCLUSIONS presence pregnancy is fourfold increased developing preeclampsia. values during are highly predictive delivery. Future research normotensive, prevent proposed.