High-Sensitivity CRP Discriminates HNF1A-MODY From Other Subtypes of Diabetes

• DOI: 10.2337/dc11-0323
• Publication Date: 2011-06-24T03:55:47Z
• Authors: Tim J. McDonald; Beverley M. Shields; Jane Lawry; Katharine R. Owen; Anna L. Gloyn; Sian Ellard; Andrew T. Hattersley
• Keywords: HNF1A; HNF1B; Glucokinase

Maturity-onset diabetes of the young (MODY) as a result mutations in hepatocyte nuclear factor 1-α (HNF1A) is often misdiagnosed type 1 or 2 diabetes. Recent work has shown that high-sensitivity C-reactive protein (hs-CRP) levels are lower HNF1A-MODY than diabetes, glucokinase (GCK)-MODY. We aim to replicate these findings larger numbers and other MODY subtypes.hs-CRP were assessed 750 patients (220 HNF1A, 245 GCK, 54 HNF4-α [HNF4A], 21 HNF1-β (HNF1B), 53 157 diabetes).hs-CRP was (median [IQR] 0.3 [0.1-0.6] mg/L) (1.40 [0.60-3.45] mg/L; P < 0.001) (1.10 [0.50-1.85] 0.001), HNF4A-MODY (1.45 [0.46-2.88] GCK-MODY (0.60 [0.30-1.80] HNF1B-MODY [0.10-2.8] = 0.07). hs-CRP discriminated from with <0.75 mg/L showing 79% sensitivity 70% specificity (receiver operating characteristic area under curve 0.84).hs-CRP forms may be used biomarker select for diagnostic HNF1A genetic testing.