Patterns of Insulin Concentration During the OGTT Predict the Risk of Type 2 Diabetes in Japanese Americans

• DOI: 10.2337/dc12-0246
• Publication Date: 2012-12-29T07:19:30Z
• Authors: Tomoshige Hayashi; Edward J. Boyko; Kyoko Kogawa Sato; Marguerite J. McN...; Donna L. Leonetti; Steven E. Kahn; Wilfred Y. Fujimoto
• Keywords: Homeostasis

OBJECTIVE To examine whether the patterns of insulin concentration during oral glucose tolerance test (OGTT) predict type 2 diabetes. RESEARCH DESIGN AND METHODS We followed 400 nondiabetic Japanese Americans for 10–11 years. Insulin concentrations at 30, 60, and 120 min a 2-h 75-g OGTT baseline were used to derive following possible insulin: pattern 1 (30-min peak, higher level 60 than min), lower or equal vs. 3 (60-min peak); 4 (120-min 30 5 min). sensitivity was estimated by homeostasis model assessment resistance (HOMA-IR) Matsuda index. secretion insulinogenic index (IGI) [Δinsulin/Δglucose (30–0 min)] disposition (IGI/HOMA-IR). RESULTS There 86 incident cases The cumulative incidence 3.2, 9.8, 15.4, 47.8, 37.5% 1, 2, 3, 4, 5, respectively. Compared with characterized lasting late response, associated significantly less as measured early response multiple-adjusted odds ratios diabetes 12.55 (95% CI 4.79–32.89) 8.34 (2.38–29.27) compared 2. This association independent sensitivity. CONCLUSIONS an strongly development