Corneal Nerve Loss Detected With Corneal Confocal Microscopy Is Symmetrical and Related to the Severity of Diabetic Polyneuropathy

• DOI: 10.2337/dc13-0193
• Publication Date: 2013-07-23T04:15:05Z
• Authors: Ioannis N. Petrop...; Uazman Alam; Hassan Fadavi; Omar Asghar; Patrick Green; Georgios Ponirakis; Andrew Marshall; Andrew J.M. Boulton; Mitra Tavakoli; Rayaz A. Malik
• Keywords: Diabetic Neuropathy; Nerve fiber

OBJECTIVE To establish if corneal nerve loss, detected using in vivo confocal microscopy (IVCCM), is symmetrical between right and left eyes relates to the severity of diabetic neuropathy. RESEARCH DESIGN AND METHODS Patients (n = 111) with type 1 2 diabetes 47 age-matched healthy control subjects underwent detailed assessment stratification into no 50), mild 26), moderate 17), severe 18) IVCCM was performed both fiber density (CNFD), branch (CNBD), length (CNFL) tortuosity coefficient were quantified. RESULTS All parameters differed significantly patients progressively worsened increasing The reduction CNFD, CNBD, CNFL all groups except CONCLUSIONS noninvasively detects which neuropathy, symmetrical, those