Real-time CGM Is Superior to Flash Glucose Monitoring for Glucose Control in Type 1 Diabetes: The CORRIDA Randomized Controlled Trial

• DOI: 10.2337/dc20-0112
• Publication Date: 2020-08-28T21:30:45Z
• Authors: Aneta Hásková; Lucie Radovnická; Lenka Petruželková; Christopher G. Pa...; George Grunberger; Eva Horová; Vendula Navrátilová; Ondřej Kádě; Martin Matoulek; Martin Prázný; Jan Šoupal
• Keywords: Adult; Blood Glucose; Glycated Hemoglobin; Male; Blood Glucose Self-Monitoring; Glycemic Control; Middle Aged; 16. Peace & justice; Hypoglycemia; 3. Good health; 03 medical and health sciences; Diabetes Mellitus, Type 1; Treatment Outcome; 0302 clinical medicine; Computer Systems; Emerging Technologies: Data Systems and Devices; Computers, Handheld; Humans; Hypoglycemic Agents; Female; Exercise

OBJECTIVE The aim of this trial was to compare the efficacy real-time and intermittently scanned continuous glucose monitoring (rtCGM isCGM, respectively) in maintaining optimal glycemic control. RESEARCH DESIGN AND METHODS In randomized study, adults with type 1 diabetes (T1D) normal hypoglycemia awareness (Gold score <4) used rtCGM (Guardian Connect Mobile) or isCGM (FreeStyle Libre) during 4 days physical activity (exercise phase) subsequent weeks at home (home phase). Primary end points were time (<3.9 mmol/L [<70 mg/dL]) range (3.9–10.0 [70–180 mg/dL]). group wore an additional masked Enlite sensor (iPro2) for 6 check bias between different sensors by systems. RESULTS Sixty T1D (mean age 38 ± 13 years; A1C 62 12 mmol/mol [7.8 1.1%]) (n = 30) 30). All participants completed study. Percentage lower among versus exercise phase (6.8 5.5% vs. 11.4 8.6%, respectively; P 0.018) (5.3 2.5% 7.3 4.4%, 0.035). Hypoglycemia differences significant most notable night. spent more (3.9–10 than throughout both (78.5 10.2% 69.7 16%, 0.0149) (75.6 9.7% 67.4 17.8%, 0.0339) phases. results robust insignificant that CGM found arm. CONCLUSIONS superior reducing improving awareness, demonstrating value alarms daily self-management.