Newborn Adiposity and Cord Blood C-Peptide as Mediators of the Maternal Metabolic Environment and Childhood Adiposity

• DOI: 10.2337/dc20-2398
• Publication Date: 2021-02-22T20:35:14Z
• Authors: Jami L. Josefson; Denise M. Scholtens; Alan Kuang; Patrick M. Catalano; Lynn P. Lowe; Alan R. Dyer; Lucia C. Petito; William L. Lowe; Boyd E. Metzger; ; Chaicharn Deeroch...; Thadchanan Tanaph...; Sukeeta Binratkae...; Wanee Manyam; Martinette Forde; Andre Greenidge; Kathleen Neblett; Paula Michele Las...; Desiree Walcott; Katie Corry; Loraine Francis; Jo-anne Irwin; Anne Langan; David R. McCance; Maureen Mousavi; Ian Young; Jennifer Gutierrez; Jennifer Jimenez; Jean M. Lawrence; David A. Sacks; Harpreet S. Takhar; Elizabeth Tanton; Wendy J. Brickman; Jennifer Howard; Jami L. Josefson; Lauren Miller; Jacqui Bjaloncik; Patrick M. Catalano; Ajuah Davis; Michaela Koontz; Larraine Presley; Shoi Smith; Amanda Tyhulski; Albert Martin Li; Ronald C. Ma; Risa Ozaki; Wing Hung Tam; Michelle Wong; Cindy Siu Man Yuen; Peter E. Clayton; Aysha Khan; Avni Vyas; Michael Maresh; Hadasse Benzaquen; Naama Glickman; Alona Hamou; Orna Hermon; Orit Horesh; Yael Keren; Yael Lebenthal; Shlomit Shalitin; Kristina Cordeiro; Jill Hamilton; Hahn Y. Nguyen; Shawna Steele; Fei Chen; Alan R. Dyer; Wenyu Huang; Alan Kuang; Maria Jimenez; Lynn P. Lowe; William L. Lowe; Boyd E. Metzger; Michael Nodzenski; Anna Reisetter; Denise Scholtens; Octavious Talbot; Paul Yim; David Dunger; Alicia Thomas; Mary Horlick; Barbara Linder; Aynur Unalp-Arida; Gilman Grave
• Keywords: Cord blood

Excessive childhood adiposity is a risk factor for adverse metabolic health. The objective was to investigate associations of newborn body composition and cord C-peptide with anthropometrics explore whether these measures mediate maternal midpregnancy glucose BMI adiposity.Data on mother/offspring pairs (N = 4,832) from the epidemiological Hyperglycemia Adverse Pregnancy Outcome (HAPO) Study HAPO Follow-up (HAPO FUS) were analyzed. Linear regression used study between anthropometrics. Structural equation modeling anthropometric as potential mediators during pregnancy outcomes.In models including adjustments, measured by sum skinfolds associated child outcomes (adjusted mean difference, 95% CI, P value) (0.26, 0.12-0.39, <0.001), z-score (0.072, 0.033-0.11, fat mass (kg) (0.51, 0.26-0.76, percentage (0.61, 0.27-0.95, (mm) (1.14, 0.43-1.86, 0.0017). demonstrated significant mediation effects (proportion total effect 2.5% 1%, respectively), (3.1%, 1.2%), (3.6%, 1.8%), (2.9%, association 22.0% 21.0%, (15.0%, 18.0%), 20.0%).Newborn independently and, along fetal hyperinsulinemia, mediates, in part, adiposity.