Association of a Healthy Lifestyle With All-Cause and Cause-Specific Mortality Among Individuals With Type 2 Diabetes: A Prospective Study in UK Biobank

• DOI: 10.2337/dc21-1512
• Publication Date: 2021-12-02T15:45:15Z
• Authors: Han Han; Yaying Cao; Chengwu Feng; Yan Zheng; Klodian Dhana; Shu Zhu; Cong Shang; Changzheng Yuan; Geng Zong
• Keywords: 2. Zero hunger; Neurodegenerative Diseases; United Kingdom; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Diabetes Mellitus, Type 2; Cardiovascular Diseases; Risk Factors; Cause of Death; Humans; Healthy Lifestyle; Prospective Studies; Life Style; Biological Specimen Banks

OBJECTIVE To evaluate the association of a healthy lifestyle, involving seven low-risk factors mentioned in diabetes management guidelines (no current smoking, moderate alcohol consumption, regular physical activity, diet, less sedentary behavior, adequate sleep duration, and appropriate social connection), with all-cause cause-specific mortality among individuals type 2 diabetes. RESEARCH DESIGN AND METHODS This study included 13,366 participants baseline from UK Biobank free cardiovascular disease (CVD) cancer. Lifestyle information was collected through questionnaire. RESULTS During median follow-up 11.7 years, 1,561 deaths were documented, 625 cancer, 370 CVD, 115 respiratory disease, 81 digestive 74 neurodegenerative disease. In multivariate-adjusted model, each lifestyle factor significantly associated mortality, hazard ratios score (scoring 6–7 vs. 0–2 unless specified) 0.42 (95% CI 0.34, 0.52) for 0.57 (0.41, 0.80) cancer 0.35 (0.22, 0.56) CVD 0.26 (0.10, 0.63) 0.28 (0.14, 0.53) 5–7 0–2). population-attributable risk analysis, 29.4% 17.9%, 40.9%) attributable to poor 0–5). The between consistent, irrespective reflecting severity (diabetes glycemic control, diabetes-related microvascular medication). CONCLUSIONS A lower due