Risk Assessment for Gastrointestinal Diseases via Clinical Dimension and Genome-Wide Polygenic Risk Scores of Type 2 Diabetes: A Population-Based Cohort Study

• DOI: 10.2337/dc23-0978
• Publication Date: 2024-01-02T21:36:04Z
• Authors: Tian Fu; Yuhao Sun; Shiyuan Lu; Jianhui Zhao; Lintao Dan; Wenming Shi; Jie Chen; Yan Chen; Xue Li
• Keywords: Duodenitis

OBJECTIVE We aimed to evaluate whether individuals with type 2 diabetes (T2D) were at higher risk of developing a wide range gastrointestinal diseases based on population-based cohort study. RESEARCH DESIGN AND METHODS This study included 374,125 participants free disorders baseline; them, 19,719 (5.27%) T2D followed-up by linking multiple medical records record disease diagnoses. Multivariable Cox models used estimate the hazard ratios (HRs) and CIs. Logistic examine associations between polygenic scores (PRS) clinical phenotypes. RESULTS During median follow-up 12.0 years, we observed new onset 15 diseases. Compared nondiabetes, had an increased gastritis duodenitis (HR 1.58, 95% CI 1.51–1.65), peptic ulcer 1.56, 1.43–1.71), diverticular 1.19, 1.14–1.24), pancreatitis 1.45, 1.24–1.71), nonalcoholic fatty liver 2.46, 2.25–2.69), cirrhosis 2.92, 2.58–3.30), biliary 1.18, 1.10–1.26), tract cancers 1.28, 1.17–1.40), hepatobiliary pancreatic cancer 2.32, 2.01–2.67). Positive PRS gastritis, duodenitis, also observed. CONCLUSIONS In this large study, found that was associated risks outcomes. suggest importance early detection prevention among patients T2D.