Clinical and Histological Correlations of Decline in Renal Function in Diabetic Patients With Proteinuria

• DOI: 10.2337/diab.43.8.1046
• Publication Date: 2013-09-19T17:22:06Z
• Authors: Jonathan L Taft; Christoper J Nolan; Stella P Yeung; Timothy D Hewitson; F Ian Martin
• Keywords: Adult; Blood Glucose; Glycated Hemoglobin; 0303 health sciences; Adolescent; Metabolic Clearance Rate; Kidney Glomerulus; Middle Aged; Kidney; Capillaries; 3. Good health; Proteinuria; 03 medical and health sciences; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Enalapril; Creatinine; Hypertension; Humans; Diabetic Nephropathies; Aged

In 47 patients with diabetic nephropathy (29 type I, 18 II) renal function and blood pressure (BP) (treated or without an angiotensin-converting enzyme [ACE] inhibitor, enalapril [10 mg], in 38 hypertensive patients) were followed over 4 years. A percutaneous biopsy was performed all initially repeated a representative 19 treated hypertension after Mean glomerular volume (MGV), interstitial fibrosis (IF), capillary volume, sclerosed glomeruli (GS) measured histomorphometrically. fall creatinine clearance (CCr) 11.8% years no difference between treatment groups of diabetes. BP both during correlated initial final serum CCr (P < 0.01). There histomorphometric differences I II groups. Initial IF 0.05) alone, MGV inversely 0.05). After years, (24.8 vs. 30.0%, P 0.01) GS (26 37%, increased significantly, increase Proteinuria HbA1 did not correlate indexes structure. this longitudinal study nephropathy, there close relation but other agents. The correlations histology at entry suggest that is co-determinant nephropathy.