Insulin is Required for Prandial Ghrelin Suppression in Humans

• DOI: 10.2337/diabetes.52.12.2923
• Publication Date: 2007-03-06T19:04:22Z
• Authors: Giuseppe Murdolo; Paola Lucidi; Chiara Di Loreto; Natascia Parlanti; Arianna De Cicco; Cristina Fatone; Carmine G. Fanelli; Geremia B. Bolli; Fausto Santeusanio; Pierpaolo De Feo
• Keywords: Hyperinsulinemia; Basal (medicine)

Accumulating evidence indicates that ghrelin plays a role in regulating food intake and energy homeostasis. In normal subjects, circulating concentrations decrease after meal ingestion increase progressively before meals. At present, it is not clear whether nutrients suppress the plasma concentration directly or indirectly by stimulating insulin secretion. To test hypothesis regulates postprandial humans, we compared effects of on levels six C-peptide-negative subjects with type 1 diabetes healthy matched for age, sex, BMI. Diabetic were studied during absence (insulin withdrawal study), intravenous infusion basal (basal study) subcutaneous administration prandial dose (prandial study). Meal suppressed (nadir at 105 min) 32 ± 4% control 57 3% diabetic patients study (P < 0.002 vs. subjects), 38 8% = 0.0016 hyperinsulinemia; P NS subjects) but did have any effect 0.001 other studies). conclusion, 1) essential meal-induced suppression, 2) availability sufficient suppression 3) lack caused severe deficiency may explain hyperphagia uncontrolled subjects.