Fish Oil Regulates Adiponectin Secretion by a Peroxisome Proliferator–Activated Receptor-γ–Dependent Mechanism in Mice

• DOI: 10.2337/diabetes.55.04.06.db05-0985
• Publication Date: 2006-05-08T22:24:58Z
• Authors: Susanne Neschen; Katsutaro Morino; Jörg C. Rossbacher; Rebecca L. Pongratz; Gary W. Cline; Saki Sono; Matthew Gillum; Gerald I. Shulman
• Keywords: CD36 Antigens; Epididymis; Male; Mice, Knockout; 0301 basic medicine; 2. Zero hunger; Transcription, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Mice, Inbred Strains; Antigens, CD36; 3. Good health; PPAR gamma; Mice; 03 medical and health sciences; Fish Oils; Adipose Tissue; Gene Expression Regulation; Animals; Epoxy Compounds; Adiponectin; Benzhydryl Compounds; DNA Primers

Adiponectin has insulin-sensitizing, antiatherogenic, and anti-inflammatory properties, but little is known about factors that regulate its secretion. To examine the effect of fish oil on adiponectin secretion, mice were fed either a control diet or isocaloric diets containing 27% safflower 27, 13.5, 8% menhaden oil. Within 15 days, feeding raised plasma concentrations two- to threefold in dose-dependent manner, remained approximately twofold higher for 7 days when was replaced by diet. 24 h, markedly induced transcription gene epididymal adipose tissue not subcutaneous fat. The increase completely blocked administration peroxisome proliferator–activated receptor (PPAR)γ inhibitor bisphenol-A-diglycidyl ether. In contrast, there no secretion PPARα-null mice. These data suggest naturally occurring potent regulator vivo it does so through PPARγ-dependent PPARα-independent manner