Caloric Restriction Per Se Is a Significant Factor in Improvements in Glycemic Control and Insulin Sensitivity During Weight Loss in Obese NIDDM Patients

• DOI: 10.2337/diacare.17.1.30
• Publication Date: 2007-03-05T22:51:27Z
• Authors: Rena R Wing; Elaine H Blair; Patricia Bononi; Marsha D Marcus; Richard Watanabe; Richard N Bergman
• Keywords: Calorie Restriction; Calorie; Caloric theory

OBJECTIVE To examine the effects of caloric restriction, independent differences in weight loss, on improvements glycemic control, fasting insulin, and insulin sensitivity. RESEARCH DESIGN AND METHODS We randomized 93 obese type II diabetic patients to two different degrees calorie restriction (1,674 or 4,185 kJ/day; 400 1,000 kcal/day) compared changes glucose, sensitivity that resulted from a comparable reduction body (11% initial weight). Insulin was assessed using minimal model analysis frequently sampled intravenous glucose tolerance tests. RESULTS Despite equal losses, subjects 1,674 kJ/day (400 kcal) condition had lower levels (7.61 vs. 10.13 mM, P = 0.03) greater (1.79 1.13, 0.04) after loss than did (1,000 calorie) condition. Subjects were restudied 15 weeks later when both groups consuming diet. who increased kJ calories) worse control spite continued whereas remained throughout further blood with loss. CONCLUSIONS Both degree magnitude have