Effect of Metformin on Postprandial Lipemia in Patients With Fairly to Poorly Controlled NIDDM

• DOI: 10.2337/diacare.17.10.1093
• Publication Date: 2007-03-05T22:51:27Z
• Authors: Jorgen Jeppesen; Ming-Yue Zhou; Y-D Ida Chen; Gerald M Reaven
• Keywords: Chylomicron

To quantify the effect of metformin on metabolism triglyceride (TG)-rich lipoprotein intestinal origin in patients with non-insulin-dependent diabetes mellitus (NIDDM) who had responded to sulfonylurea but still fasting hyperglycemia.Sixteen NIDDM demonstrated a fall plasma glucose concentration > 2.2 mmol/l response glipizide treatment continued have concentrations 8.3 were studied. Fasting glucose, GHb, lipid and determined, resistance insulin-mediated disposal was estimated by measuring steady-state (SSPG) at end 180-min infusion somatostatin, insulin. In addition, insulin, TG measured frequent intervals from 0800 2400, eating breakfast lunch 1200. Vitamin A also given lunch, retinyl ester content chylomicron (Svedberg flotation constant [Sf] 400) remnant (Sf 20-400) fractions used postprandial TG-rich 1200 2400.Fasting (6.8 +/- 0.4 vs. 10.5 mmol/l), GHb levels (7.9 0.3 10.8 0.5%), day-long all significantly lower after (P < 0.001), which associated significant 0.001) SSPG (11.0 0.9 9.6 0.6 mmol/l). free fatty acids, following treatment. Postprandial 33 5.7% both (32 7.2%, P (26 7.0%, 0.005) fractions.Addition sulfonylurea-treated less than optimal glycemic control improved control, insulin concentrations, decrease lipoproteins origin. All these changes might be expected risk coronary heart disease.