Impaired skin microvascular function in children, adolescents, and young adults with type 1 diabetes.

• DOI: 10.2337/diacare.23.2.215
• Publication Date: 2007-03-05T22:51:27Z
• Authors: F Khan; T A Elhadd; S A Greene; J J Belch
• Keywords: Sodium nitroprusside

Vascular disease in type 1 diabetes is a complex and multifactorial process, which probably begins childhood association with the onset of diabetes. To determine possible factors involved, we measured microvascular responses to endothelium-dependent (acetylcholine) endothelium-independent (sodium nitroprusside) vasodilators 56 patients (aged 9-22 years) 22 control subjects.Skin perfusion was at dorsum foot using laser Doppler flowmetry during low-current iontophoresis acetylcholine sodium nitroprusside. Maximum vasodilator function local 44 degrees C skin heating.Vascular were significantly reduced compared subjects: (P<0.01, analysis variance [ANOVA]), nitroprusside ANOVA), heating (P<0.02. Mann-Whitney U test). Endothelium-dependent related duration (r = -0.38, P<0.01) glycemic 0.37, P<0.01). Significant correlations found patient group between 0.28, P<0.05) but not heating, suggesting that common factor (e.g., nitric oxide activity) may be responsible for abnormal vascular these chemicals.Early changes are present young diabetes, long before initial clinical presentation. These abnormalities interactions structural functional endothelium, smooth muscle, activity.