Factors Responsible for Development From Normal Glucose Tolerance to Isolated Postchallenge Hyperglycemia

• DOI: 10.2337/diacare.26.4.1211
• Publication Date: 2007-03-05T22:51:27Z
• Authors: Haruhiko Suzuki; Mitsuo Fukushima; Masaru Usami; Masaki Ikeda; Ataru Taniguchi; Yosikatsu Nakai; Toshifumi Matsuura; Akira Kuroe; Koichiro Yasuda; Takeshi Kurose; Yutaka Seino; Yuichiro Yamada
• Keywords: Homeostasis; Glucose tolerance test

OBJECTIVE—Isolated postchallenge hyperglycemia (IPH), defined as fasting plasma glucose (FPG) level <7.0 mmol/l and 2-h (PG) ≥11.1 mmol/l, is a subtype of early-stage diabetes. This study evaluates the metabolic profiles insulin secretion sensitivity in IPH to clarify factors responsible for development this form type 2 RESEARCH DESIGN AND METHODS—We conducted cross-sectional analysis 231 Japanese men aged 20–70 years. The subjects were classified into following three groups, based on results 75-g oral tolerance test (OGTT): 1) normal (NGT), FPG <6.1 PG <7.8 (n = 89); 2) impaired (IGT), 7.8–11.1 94); 3) 48). We compared groups (insulinogenic index) (index resistance using homeostasis model assessment [HOMA-IR]). RESULTS—The insulinogenic index was lowest (P < 0.001 versus NGT). HOMA-IR IGT significantly higher than NGT group 0.001), but both similar. By linear regression analysis, rather or more significant factor IPH. CONCLUSIONS—Subjects with exhibited distinctly early-phase only mild resistance, indicating that reduced primary determinant deterioration from diabetes these subjects.