Glycosylated Serum Albumin: An Intermediate Index of Diabetic Control

• DOI: 10.2337/diacare.6.5.501
• Publication Date: 2007-03-05T22:51:27Z
• Authors: Ian R Jones; David R Owens; Sheila Williams; Robert E J Ryder; Anthony J Birtwell; Martin K Jones; Kimani Gicheru; Tom M Hayes
• Keywords: Metabolic control analysis; Glycosylated haemoglobin

Glycosylated hemoglobin (HbA1) is widely used as an index of glycemic control in diabetic patients. However, due to the long survival time erythrocytes (120 days), it remains elevated for several weeks after improved control. Other plasma proteins are similarly glycosylated, and glycosylated serum albumin (GSA) has a shorter half-life (20 should detect changes earlier. Fasting blood glucose (FBG), GSA, HbA1 were measured weekly newly diagnosed patients (N = 12) 8 wk beginning treatment. After 4 wk, similar fall FBG GSA levels, i.e., 72% 58% respectively, was observed. In contrast, fell significantly less (P < 0.01), by only 39% its initial value. By there no significant difference between percentage reduction three indices Therefore, provides clinician with earlier objective evidence metabolic response therapeutic intervention can be regarded intermediate