Real-time CGM is Superior to Flash Glucose Monitoring for Glucose Control in Type 1 diabetes: The CORRIDA Randomized Control Trial

• DOI: 10.2337/figshare.12767927.v1
• Publication Date: 2020-08-28T16:04:15Z
• Authors: Aneta Hásková; Lucie Radovnická; Lenka Petruželková; Christopher G. Pa...; George Grunberger; Eva Horová; Vendula Navrátilová; Ondřej Kádě; Martin Matoulek; Martin Prázný; Jan Šoupal
• Keywords: Adult; Blood Glucose; Glycated Hemoglobin; Male; Blood Glucose Self-Monitoring; Glycemic Control; Middle Aged; 16. Peace & justice; Hypoglycemia; 3. Good health; 03 medical and health sciences; Diabetes Mellitus, Type 1; Treatment Outcome; 0302 clinical medicine; Computer Systems; Emerging Technologies: Data Systems and Devices; Computers, Handheld; Humans; Hypoglycemic Agents; Female; Exercise

Background: The aim of this trial was to compare the efficacy real-time and <a>intermittently-scanned </a>continuous glucose monitoring (rtCGM isCGM, respectively) in maintaining optimal glycemic control. <p>Methods: <a>In randomized study, adults with T1D normal hypoglycemia</a><b> </b>awareness (GOLD score <4) used rtCGM (Guardian Connect Mobile) or isCGM (Freestyle Libre) during 4 days physical activity (exercise phase) subsequent weeks at home (home phase). Primary endpoints were time hypoglycemia (<3.9 mmol/l [<70 mg/dl]) range (3.9-10.0 [70-180 mg/dl]). group wore an additional masked Enlite sensor (iPro2) for 6 check bias between different sensors by systems.<b></b></p> <p>Results: Sixty (mean age 38±13 years, A1C 62±12 mmol/mol [7.8±1.1%]) (n=30) (n=30). All participants completed study. Percentage mg/dl)) lower among vs. exercise phase (6.8±5.5% 11.4±8.6%, respectively; p=0.018) (5.3±2.5% 7.3±4.4%, p=0.035). Hypoglycemia differences significant most notable night. spent more (3.9-10 than throughout both (78.5±10.2% 69.7±16%, p=0.0149) (75.6±9.7% 67.4±17.8%, p=0.0339) phases. results robust insignificant that CGM found arm.<a></a></p> <p>Conclusion: superior reducing improving awareness, demonstrating value alarms daily diabetes self-management.</p> <br>