<strong>Bridging Energy Need and Feeding Behavior: The Impact of eIF2α Phosphorylation in AgRP Neurons</strong>

• DOI: 10.2337/figshare.23713254.v1
• Publication Date: 2023-07-21T17:56:11Z
• Authors: Kwang Kon Kim; Tae Hwan Lee; Byong Seo Park; Dasol Kang; Dong Hee Kim; Bora Jeong; Jin Woo Kim; Hye Rim Yang; Han Rae Kim; Sungho Jin; Sung Hoon Back; Jeong Woo Park; Jae Geun Kim; Byung Ju Lee
• Keywords: eIF2; Mediator

&lt;p&gt; Eukaryotic translation initiation factor 2α (eIF2α) is a key mediator of the endoplasmic reticulum (ER) stress–induced unfolded protein response (UPR). In mammals, eIF2α phosphorylated by overnutrition-induced ER stress and related to development obesity. Here, we studied function (p-eIF2α) in AgRP neurons using mouse model (&lt;em&gt;AgRP&lt;/em&gt;eIF2αA/A) with an neuron–specific substitution from Ser 51 Ala eIF2α, which impairs phosphorylation neurons. These &lt;em&gt;AgRP&lt;/em&gt;eIF2αA/A mice showed decreases starvation-induced neuronal activity food intake also revealed increased responsiveness leptin. Intriguingly, impairment produced expression UPR autophagy genes Collectively, these findings suggest that regulates affecting intracellular responses such as during starvation, thereby participating homeostatic control whole-body energy metabolism.&lt;/p&gt;