<b>Inhibiting phosphatidylcholine remodeling in adipose tissue increases insulin sensitivity</b>

• DOI: 10.2337/figshare.24018636.v1
• Publication Date: 2023-08-28T15:21:32Z
• Authors: Mulin He; Zhiqiang Li; Victoria Sook Ken...; Meixia Pan; Xianlin Han; Oleg Evgrafov; Xian-Cheng Jiang

&lt;p&gt;Cell membrane phosphatidylcholine composition is regulated by lysophosphatidylcholine acyltransferase (LPCAT); changes in saturation are implicated metabolic disorders. Here, we identified LPCAT3 as the major isoform of LPCAT adipose tissues and created adipocyte-specific &lt;i&gt;Lpcat3&lt;/i&gt;-knockout mice to study tissue lipid metabolism. Transcriptome sequencing plasma adipokine profiling were used investigate how regulates insulin signaling. deficiency reduced polyunsaturated phosphatidylcholines adipocyte membranes, increasing sensitivity. influenced rafts, which activated receptors AKT tissue, attenuated diet-induced resistance. Conversely, higher activity from &lt;i&gt;ob/ob&lt;/i&gt;, &lt;i&gt;db/db&lt;/i&gt;, high-fat diet-fed Adding mature human or mouse adipocytes vitro worsened We suggest that targeting manipulate phospholipid a new strategy treat resistance.&lt;/p&gt;