<b>Proteomic and metabolomic signatures in prediabetes progressing to diabetes or reversing to normoglycemia within one-year</b>

• DOI: 10.2337/figshare.27961080.v1
• Publication Date: 2025-01-02T20:35:26Z
• Authors: Marko Barovic; Joke Johanna Hahn; Annett Heinrich; Trishla Adhikari; Peter Schwarz; Peter Mirtschink; Alexander Funk; Stefan Kabisch; Andreas FH Pfeiffe; Matthias Blüher; Jochen Seissler; Norbert Stefan; Robert Wagner; Andreas Fritsche; Reiner Jumpertz v...; Sarantis Chlamydas; Hani Harb; Christos S. Mantz...; Triantafyllos Cha...; Annette Schürmann; Andreas L. Birken...; Michael Roden; Michele Solimena; Stefan R Bornstein; Nikolaos Perakakis
• Keywords: Prediabetes; Reversing

&lt;p dir="ltr"&gt;Objective: Progression of prediabetes to type 2 diabetes has been associated with beta cell dysfunction, whereas its remission normoglycemia related improvement insulin sensitivity. To understand the mechanisms and identify potential biomarkers trajectories, we compared proteomics metabolomics profile people progressing or reversing within a year. &lt;/p&gt;&lt;p dir="ltr"&gt;Research Design Methods: The fasting plasma concentrations 1389 proteins fasting, 30 min 120 post-oral glucose tolerance test 152 metabolites were measured in up 134 individuals new-onset diabetes, normal tolerance. For 108 participants analysis was repeated samples from one-year before, when all had prediabetes.&lt;/p&gt;&lt;p dir="ltr"&gt;Results: 14 higher population before they correlated indices Higher levels Dicarbonyl/L-xylulose-reductase Glutathione S-transferase A3 at prediabetic state increased risk later. Pathway pointed towards differences immune response between versus that already recognizable prior, baseline. Area-under-the-curve during OGTT Intermediate-Density-Lipoprotein (IDL)-particles, IDL-Apolipoprotein B, IDL-Cholesterol normoglycemia. concentration glutamate diabetes.&lt;/p&gt;&lt;p dir="ltr"&gt;Conclusions: We new candidates progression Pathways regulating are trajectories&lt;/p&gt;