<b>Isolated Glucosuria in Adolescence and Early-Onset </b><b>Diabetes</b><b>: A Nationwide Cohort Study of 1.6 million Adolescents</b>

• DOI: 10.2337/figshare.28395116.v1
• Publication Date: 2025-02-26T17:59:22Z
• Authors: Adi Vinograd; Tsahi T. Lerman; Orit Pinhas-Hamiel; Aya Bardugo; Cole D. Bendor; Estela Derazne; Josef Coresh; Ofir Vinograd; Miri Lutski; Inbar Zucker; Michal Bromberg; Tamar Fishman; Gabriel Chodick; Hertzel C Gerstein; Asaf Vivante; Adi Leiba; Arnon Afek; Amir Tirosh; Boris Fishman; Gilad Twig

&lt;p dir="ltr"&gt;Objective Assessing diabetes risk in adulthood among adolescents with isolated glucosuria. Research Design and Methods Included were (16-19 years) examined before military service between 1993-2015. Data linked the Israeli National Diabetes Registry. Glucosuria was confirmed following normal renal function glucose tolerance tests. Cox models applied. Results The study included 1,611,467 adolescents, of whom 755 (0.05%) had latter group a higher proportion males (75% vs 57%) lower BMI≥85th percentile (10.4% 16.3%) compared to non-glucosuric (all P &lt;0.001). During follow-up, 10,328 cases recorded an incidence rate 87.5 43.3 per 100,000 person-years for those vs. without glucosuria, respectively. Individuals glucosuria adjusted HR 2.17 (95%CI, 1.17–4.04) diabetes. Conclusions is associated increased early onset diabetes.&lt;/p&gt;