<b>Hepatic PKA Mediates the Liver and Pancreatic Alpha-Cell Crosstalk</b>

• DOI: 10.2337/figshare.28589564.v1
• Publication Date: 2025-03-17T16:08:17Z
• Authors: Kehan Bao; Jason Berger; Erqian Na; Qi Su; Gabor Halasz; Mark Sleeman; Haruka Okamoto
• Keywords: Crosstalk; Alpha (finance)

&lt;p dir="ltr"&gt;Glucagon stimulates hepatic glucose production, in part by promoting the uptake and catabolism of amino acids. Inhibition liver glucagon receptor (GCGR) results elevated plasma acids, which triggers proliferation pancreatic alpha-cells, forming a liver-alpha cell loop. This study aims to delineate signaling molecules downstream GCGR mediate We knocked down GCGR, its G-coupled protein GNAS, two GNAS effectors, PKA EPAC2 (RAPGEF4). Mice with knockdown had similar suppression acid genes, hyperaminoacidemia, alpha hyperplasia, but did not. then demonstrated that activating was sufficient reverse hyperaminoacidemia hyperplasia caused blockade. These suggest signals through control metabolism, plays critical role loop.&lt;/p&gt;