A comparative analysis of glycemic metrics derived from three continuous glucose monitoring (CGM) systems

• DOI: 10.2337/figshare.28611818.v1
• Publication Date: 2025-04-08T15:50:42Z
• Authors: Guido Freckmann; Stephanie Wehrstedt; Manuel Eichenlaub; Stefan Pleus; Manuela Link; Nina Jendrike; Sükrü Öter; Derek Brandt; Cornelia Haug; Delia Waldenmaier

<p dir="ltr">Objective</p><p dir="ltr">This study analyzed the differences in continuous glucose monitoring (CGM)-derived metrics between three current-generation systems and evaluated their impact on therapeutic decision-making. </p><p dir="ltr">Research Design and Methods</p><p dir="ltr">23 participants wore the FreeStyle Libre 3, Dexcom G7 and Medtronic Simplera CGM systems for 14 days in parallel. CGM metrics were calculated for each participant and CGM system separately.</p><p dir="ltr">Results </p><p dir="ltr">The apparent glucose profile was influenced by the used CGM system, resulting in substantially different glycemic metrics between the three systems. </p><p dir="ltr">Agreement between FreeStyle Libre 3 and Dexcom G7 was higher than with Medtronic Simplera, which showed lower glucose levels on average. There were marked intra-participant discrepancies which would have resulted in different therapeutic recommendations. </p><p dir="ltr">Conclusions</p><p dir="ltr">The CGM systems indicated discordant glycemic metrics which should be considered in diabetes therapy. Different CGM systems should provide the same glucose readings and CGM-derived metrics when used by the same person. </p><p><br></p>