Interleukin-17 Genes Polymorphisms are Significantly Associated with Cutaneous T-cell Lymphoma Susceptibility

• DOI: 10.2340/actadv.v102.2416
• Publication Date: 2022-08-16T08:28:53Z
• Authors: Karol Kołkowski; Jolanta Gleń; Berenika Olszewska; Monika Zabłotna; Roman J. Nowicki; Małgorzata Sokoł...
• Keywords: Cutaneous T-cell lymphoma; Heterozygote advantage

Tumour microenvironment has an important effect on the progression of cutaneous T-cell lymphomas. Using PCR with sequence-specific primers, this study analysed single-nucleotide polymorphisms in interleukin-17 genes 150 patients lymphoma. GG homozygote rs8193036 A/G interleukin-17A gene occurred less commonly lymphoma group; however, polymorphism experience significantly intense pruritus. Conversely, rs2397084 AG heterozygote interleukin-17F is more common population. In addition, there were significant differences frequencies genotypes when comparing early (Ia to IIa) and advanced stages (IIb, III IV) neoplasms. A similar result been shown comparison between Sézary syndrome mycosis fungoides. The current data may serve as a possible explanation for increased bacterial infection rates course lymphoma, especially caused by Staphylococcus aureus. summary, specific occur different healthy patients. Moreover, genetic predisposition several be factor causing impaired immune defence