Novel r(2)(p25q31) Cytogenetic Abnormality in a Pediatric Patient with Acute Leukemia of Ambiguous Lineage

• DOI: 10.2350/14-07-1521-cr.1
• Publication Date: 2014-12-01T21:11:15Z
• Authors: Jaehyup Kim; Lihong Bu; Prasad R. Koduru; Kathleen S. Wilson; Franklin S. Fuda; Kirthi R. Kumar; Charles F. Timmons; Tamra L. Slone; Hung S. Luu
• Keywords: Lineage (genetic); Abnormality; Immunophenotyping

We describe a case of acute leukemia ambiguous lineage with novel cytogenetic abnormality. A 1-year-old boy presented abnormal complete blood count findings, and was found to have blasts mild dysgranulopoiesis. The showed immunophenotypic evidence myeloid T-lineage differentiation. Subsequent analysis r(2)(p25q31) as the sole stem line defect clonal evolution. While abnormalities can critical role in classification prognostication lymphoblastic leukemia, significance remains unclear. This finding has not been reported previously best our knowledge.