HOXD9 aggravates the development of cervical cancer by transcriptionally activating HMCN1

• DOI: 10.23736/s0031-0808.20.03911-7
• Publication Date: 2022-01-20T11:12:46Z
• Authors: Dan WEN; Li WANG; Songhong TAN; Rong TANG; Weimin XIE; Shanyan LIU; Caixia TANG; Yingxin HE
• Keywords: HeLa

To detect HOXD9 levels in cervical cancer species and to explore the relationship between level prognosis patients. We also verify influence of on metastatic abilities cancer.HOXD9 were detected. Its clinical features patients was analyzed. Regulatory effects migratory invasive capacities C33-A HeLa cells evaluated by Transwell assay. Subsequently, downstream gene predicted bioinformatics analysis confirmed luciferase The involvement HMCN1 regulating ability finally explored rescue experiments.HOXD9 upregulated its positively correlated rates lymphatic metastasis distant metastasis. High a poor prognosis. Overexpression promoted cells. identified be binding HOXD9. It responsible for HOXD9-regulated is species. closely linked rate Through level, stimulates