Enlarging melanocytic lesions with peripheral globular pattern: a dermoscopic and confocal microscopy study

• DOI: 10.23736/s2784-8671.19.06471-x
• Publication Date: 2021-10-07T22:10:38Z
• Authors: Anna CARBONE; Flavia PERSECHINO; Giovanni PAOLINO; Carlo COTA; Paolo PIEMONTE; Chiara FRANCESCHINI; Laura EIBENSCHUTZ; Angela FERRARI; Pierluigi BUCCINI; Pasquale FRASCIONE; Stefano CALVIERI; Marco ARDIGÒ
• Keywords: Dermatoscopy

BACKGROUND: Enlarging melanocytic lesions with peripheral globular pattern (EMLPGP) are a pitfall in dermoscopy. Our aim was to evaluate the meaning of EMLPGP and assess use dermoscopy reflectance confocal microscopy (RCM) order improve clinical management this subtype lesions.METHODS: A total 135 were recruited and, accordingly features, removed; later, an expert dermoscopist reviewed blinded histology. Moreover, subgroup 63 who underwent also RCM, by confocalist.RESULTS: Patients had median age 41 years old female prevalence (61.5%). The main anatomic site trunk (86%). Histology excised disclosed 116 nevi (86%; P<0.0001) 19 melanomas (14%). On dermoscopy, statistical significance detected for small globules that observed 106 cases (78.5%; P<0.0001), while distribution color did not impact diagnosis prediction, as well age, sex or any other patient profile. Considering atypical cytology irregular architecture 100% (P<0.0001).CONCLUSIONS: study shows EMLPGPs detectable every can be especially high risk patients over-excision lesions. presence should evaluated considering overall dermoscopic features. RCM contribute significantly trough detection cyto-architectural atypia. Therefore, combination optimize reduction harmless